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Review
. 2013 Aug;14(8):664-9.
doi: 10.1631/jzus.BQICC701.

Interleukin-17 and acute coronary syndrome

Sheng-an Su  1 , Hong Ma, Li Shen, Mei-xiang Xiang, Jian-an Wang
Affiliations
Review

Interleukin-17 and acute coronary syndrome

Sheng-an Su et al. J Zhejiang Univ Sci B. 2013 Aug.

Abstract

Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear, we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism.

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Conflict of interest statement

Compliance with ethics guidelines: Sheng-an SU, Hong MA, Li SHEN, Mei-xiang XIANG, and Jian-an WANG declare that they have no conflict of interest.

This article does not contain any studies with human or animal subjects performed by any of the authors.

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