Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Aug;14(8):688-95.
doi: 10.1631/jzus.B1300137.

Metabolic remodeling in chronic heart failure

Jing Wang  1 , Tao Guo
Affiliations
Review

Metabolic remodeling in chronic heart failure

Jing Wang et al. J Zhejiang Univ Sci B. 2013 Aug.

Abstract

Although the management of chronic heart failure (CHF) has made enormous progress over the past decades, CHF is still a tremendous medical and societal burden. Metabolic remodeling might play a crucial role in the pathophysiology of CHF. The characteristics and mechanisms of metabolic remodeling remained unclear, and the main hypothesis might include the changes in the availability of metabolic substrate and the decline of metabolic capability. In the early phases of the disease, metabolism shifts toward carbohydrate utilization from fatty acids (FAs) oxidation. Along with the progress of the disease, the increasing level of the hyperadrenergic state and insulin resistance cause the changes that shift back to a greater FA uptake and oxidation. In addition, a growing body of experimental and clinical evidence suggests that the improvement in the metabolic capability is likely to be more significant than the selection of the substrate.

PubMed Disclaimer

Conflict of interest statement

Compliance with ethics guidelines: Jing WANG and Tao GUO declare that they have no conflict of interest.

This article does not contain any studies with human or animal subjects performed by any of the authors.

Figures

Fig. 1
Fig. 1
Mechanism of fetal metabolic phenotype The decline of FAs metabolism and the incline of glucose metabolism
Fig. 2
Fig. 2
Mechanism of non-fetal metabolic phenotype The decline of glucose metabolism and the incline of FAs metabolism
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abozguia K, Clarke K, Lee L, Frenneaux M. Modification of myocardial substrate use as a therapy for heart failure. Nat Clin Pract Cardiovasc Med. 2006;3(9):490–498. doi: 10.1038/ncpcardio0583. - DOI - PubMed
    1. Abozguia K, Shivu GN, Ahmed I, Phan TT, Frenneaux MP. The heart metabolism: pathophysiological aspects in ischaemia and heart failure. Curr Pharm Des. 2009;15(8):827–835. doi: 10.2174/138161209787582101. - DOI - PubMed
    1. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, et al. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005;1(4):259–271. doi: 10.1016/j.cmet.2005.03.002. - DOI - PubMed
    1. Ardehali H, Sabbah HN, Burke MA, Sarma S, Liu PP, Cleland JG, Maggioni A, Fonarow GC, Abel ED, Campia U, et al. Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail. 2012;14(2):120–129. doi: 10.1093/eurjhf/hfr173. - DOI - PMC - PubMed
    1. Ashrafian H, Frenneaux MP. Metabolic modulation in heart failure: the coming of age. Cardiovasc Drugs Ther. 2007;21(1):5–7. doi: 10.1007/s10557-007-6000-z. - DOI - PubMed