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. 2013 Oct:126:211-4.
doi: 10.1016/j.envres.2013.07.002. Epub 2013 Jul 27.

The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling

M P Longnecker  1 , K Harbak, G E Kissling, J A Hoppin, M Eggesbo, T A Jusko, J Eide, H M Koch
Affiliations

The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling

M P Longnecker et al. Environ Res. 2013 Oct.

Abstract

In urine specimens that were collected from pregnant women in a large cohort, 24% contained more than 10 ng/ml of total bisphenol A (BPA), suggesting external contamination. Therefore, we conducted an investigation of the source(s) of extraneous BPA in the specimens. We found that under the conditions used to collect urine specimens in the epidemiologic study, contamination with BPA occurred, and by two separate mechanisms.

Keywords: BPA; Bisphenol A; Contamination; LOD; LOQ; MoBa; Norwegian Mother and Child Cohort Study; QC; SD; Urine specimen collection; bisphenol A; limit of detection; limit of quantitation; quality control; standard deviation.

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Figures

Figure 1
Figure 1
A: Concentration of conjugated BPA from Experiment 1. B: Concentration of free BPA from Experiment 1. C: Concentration of free BPA in Experiment 2. P values for contrasts indicated by brackets: I, <0.0001; II, 0.003; III, <0.0001; IV, 0.0009; V, 0.0001; and VI, <0.0001.
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