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Review
. 2013 Dec;65(15):2016-22.
doi: 10.1016/j.addr.2013.07.013. Epub 2013 Jul 27.

Carbon nanotubes as vaccine scaffolds

David A Scheinberg  1 , Michael R McDevitt, Tao Dao, J Justin Mulvey, Evan Feinberg, Simone Alidori
Affiliations
Review

Carbon nanotubes as vaccine scaffolds

David A Scheinberg et al. Adv Drug Deliv Rev. 2013 Dec.

Abstract

Carbon nanotubes display characteristics that are potentially useful in their development as scaffolds for vaccine compositions. These features include stability in vivo, lack of intrinsic immunogenicity, low toxicity, and the ability to be appended with multiple copies of antigens. In addition, the particulate nature of carbon nanotubes and their unusual properties of rapid entry into antigen-presenting cells, such as dendritic cells, make them especially useful as carriers of antigens. Early attempts demonstrating carbon nanotube-based vaccines can be used in both infectious disease settings and cancer are promising.

Keywords: Carbon nanotubes; adjuvants; antigen presenting cells; vaccines.

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