Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul 29;5(8):2924-32.
doi: 10.3390/nu5082924.

Gastric lipase secretion in children with gastritis

Przemyslaw J Tomasik  1 , Andrzej Wędrychowicz, Iwona Rogatko, Andrzej Zając, Krzysztof Fyderek, Krystyna Sztefko
Affiliations

Gastric lipase secretion in children with gastritis

Przemyslaw J Tomasik et al. Nutrients. .

Abstract

Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10), the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14) and the control group including healthy adolescents (n = 14). Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005) and the control group (p < 0.005). Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003) and the HPG group (p < 0.01). We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The mean activity of human gastric lipase (HGL) and mean concentrations of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) in the study groups (non-HPG—non-Helicobacter pylori gastritis group, HPG—Helicobacter pylori gastritis group, CG—control group).
Figure 2
Figure 2
Correlation between activity of HGL and concentration of GIP in all studied patients.
See this image and copyright information in PMC

References

    1. DeNigris S.J., Hamosh M., Kasbekar D.K., Lee T.C., Hamosh P. Lingual and gastric lipases: Species differences in the origin of prepancreatic digestive lipases and in the localization of gastric lipase. Biochim. Biophys. Acta. 1988;959:38–45. doi: 10.1016/0005-2760(88)90147-6. - DOI - PubMed
    1. Carrière F., Raphel V., Moreau H., Bernadac A., Devaux M.A., Grimaud R., Barrowman J.A., Bénicourt C., Junien J.L., Laugier R., et al. Dog gastric lipase: Stimulation of its secretion in vivo and cytolocalization in mucous pit cells. Gastroenterology. 1992;102:1535–1545. - PubMed
    1. Hamosh M., Henderson T.R., Hamosh P. Gastric lipase and pepsin activities in the developing ferret: Nonparallel development of the two gastric digestive enzymes. J. Pediatr. Gastroenterol. Nutr. 1998;26:162–166. doi: 10.1097/00005176-199802000-00007. - DOI - PubMed
    1. Moreau H., Bernadac A., Gargouri Y., Benkouka F., Laugier R., Verger R. Immunocytolocalization of human gastric lipase in chief cells of the fundic mucosa. Histochemistry. 1989;91:419–423. doi: 10.1007/BF00493829. - DOI - PubMed
    1. Lindquist S., Hernell O. Lipid digestion and absorption in early life: An update. Opin. Clin. Nutr. Metab. Care. 2010;13:314–320. doi: 10.1097/MCO.0b013e328337bbf0. - DOI - PubMed

Publication types

LinkOut - more resources