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. 2013 Oct;31(8):516-21.
doi: 10.3109/07357907.2013.826239. Epub 2013 Jul 31.

Soluble interleukin-6 receptor is a prognostic marker for relapse-free survival in estrogen receptor-positive breast cancer

Hye Sung Won  1 , Young Ae Kim, Jun Sang Lee, Eun Kyoung Jeon, Ho Jung An, Der Sheng Sun, Yoon Ho Ko, Jeong Soo Kim
Affiliations

Soluble interleukin-6 receptor is a prognostic marker for relapse-free survival in estrogen receptor-positive breast cancer

Hye Sung Won et al. Cancer Invest. 2013 Oct.

Abstract

Considering the protumorigenic roles of interleukin-6 (IL-6) transsignaling, we assessed the serum levels of IL-6, soluble interleukin-6 receptor (sIL-6R), and soluble glycoprotein 130 (sgp130) in 143 patients with breast cancer. Serum levels of IL-6 were elevated with advanced T and N stage. Serum levels of sIL-6R were lower in patients with estrogen receptor-positive cancer. The median values of IL-6 and sgp130 did not differ between patients with recurrence and those without recurrence. However, higher serum levels of sIL-6R at diagnosis were associated with significantly shorter relapse-free survival in patients with estrogen receptor-positive breast cancer.

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