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. 2013 Aug 1:11:131.
doi: 10.1186/1477-7525-11-131.

Health-related quality of life and survival in Chinese patients with chronic liver disease

Feng Gao, Ru Gao, Guang Li, Zhan Min Shang, Jian Yu Hao

Health-related quality of life and survival in Chinese patients with chronic liver disease

Feng Gao et al. Health Qual Life Outcomes. .

Abstract

Background: To investigate the relationship between health-related quality of life (HRQOL) and survival in Chinese patients with chronic liver disease (CLD).

Methods: HRQOL was measured with the Chinese version of Short Form 36 (SF-36). SF-36 scores, demographic and clinical data were collected at baseline and after 18 months follow-up. Kaplan-Meier and Cox Proportional Hazard Regression survival analyses were used for interpretation of data. Surviving patients were censored in the analyses.

Results: A total of 415 Chinese patients with CLD and 86 healthy controls were enrolled. During the follow-up period 50 patients died. SF-36 scores in healthy controls and surviving patients were higher compared with those in deceased patients. Scores of physical component summary (PCS) in healthy controls, surviving and deceased patients were 54.1 ± 5.2, 48.9 ± 7.7 and 33.5 ± 8.2 respectively (p < 0.001). Scores of mental component summary (MCS) in healthy controls, surviving and deceased patients were 56.6 ± 8.2, 53.0 ± 5.6 and 37.1 ± 12.1 (p < 0.001) respectively. Survival was significantly associated with PCS and MCS scores, and the presence of ascites.

Conclusions: HRQOL was associated with survival in patients with CLD. PCS and MCS scores were predictors of survival.

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Figures

Figure 1
Figure 1
Kaplan-Meier analysis showing association between PCS scores and survival, log-rank P < 0.001.
Figure 2
Figure 2
Kaplan-Meier analysis showing association between MCS scores and survival, log-rank p < 0.001.
Figure 3
Figure 3
Kaplan-Meier analysis showing association between PCS scores plus present ascites and survival, log-rank p < 0.001.
Figure 4
Figure 4
Kaplan-Meier analysis showing association between MCS scores plus present ascites and survival, log-rank p < 0.001.
See this image and copyright information in PMC

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