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Comment
. 2013 Aug;84(2):228-30.
doi: 10.1038/ki.2013.128.

The calcium-sensing receptor directly regulates proximal tubular functions

Carsten A Wagner  1
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Free article
Comment

The calcium-sensing receptor directly regulates proximal tubular functions

Carsten A Wagner. Kidney Int. 2013 Aug.
Free article

Abstract

Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions.

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