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Comparative Study
. 2013 Oct;87(19):10912-5.
doi: 10.1128/JVI.01839-13. Epub 2013 Jul 31.

AIDS alters the commensal plasma virome

Linlin Li  1 , Xutao Deng, Piyada Linsuwanon, David Bangsberg, Mwebesa Bosco Bwana, Peter Hunt, Jeffrey N Martin, Steven G Deeks, Eric Delwart
Affiliations
Comparative Study

AIDS alters the commensal plasma virome

Linlin Li et al. J Virol. 2013 Oct.

Abstract

We compared the plasma viromes of HIV-infected subjects with low versus high CD4(+) T cell counts from the United States and Uganda by using deep sequencing and detected HIV, hepatitis C virus, hepatitis B virus, GB virus C, anellovirus, and human endogenous retrovirus (HERV) reads. An increase in the proportion of reads for anelloviruses, a family of highly prevalent and genetically diverse human viruses, was seen in subjects with AIDS from both countries. The proportion of endogenous human retrovirus reads was increased in AIDS subjects from Uganda but not the United States. Progression to AIDS is therefore associated with changes in the plasma concentration of commensal viruses.

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