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. 2013 Aug;20(4):e345-8.
doi: 10.3747/co.20.1356.

Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial

P Haddad  1 , F Amouzgar-Hashemi, S Samsami, S Chinichian, M A Oghabian
Affiliations

Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial

P Haddad et al. Curr Oncol. 2013 Aug.

Abstract

To evaluate an Aloe vera lotion for prevention of radiation-induced dermatitis, all patients with a prescription of radiotherapy to a minimum dose of 40 Gy were eligible provided that their treatment area could be divided into two symmetrical halves. Patients were given a lotion of Aloe vera to use on one half of the irradiated area, with no medication to be used on the other half. The grade of dermatitis in each half was recorded weekly until 4 weeks after the end of radiotherapy. The trial enrolled 60 patients (mean age: 52 years; 67% women). Most patients had breast cancer (38%), followed by pelvic (32%), head-and-neck (22%), and other cancers (8%). Field size was 80-320 cm(2) (mean: 177 cm(2)), and the dose of radiotherapy was 40-70 Gy (mean: 54 Gy). Concurrent chemotherapy was administered in 20 patients. From week 4 to week 6 of radiotherapy and then at weeks 2 and 4 after radiotherapy, the mean grade of dermatitis with and without Aloe vera was 0.81 and 1.10 (p < 0.001), 0.96 and 1.28 (p < 0.001), 1.00 and 1.57 (p = 0.006), 0.59 and 0.79 (p = 0.003), and 0.05 and 0.21 (p = 0.002) respectively. Age and radiation field size had a significant effect on the grade of dermatitis. Based on these results, we conclude that the prophylactic use of Aloe vera reduces the intensity of radiationinduced dermatitis.

Keywords: Aloe vera; prevention; radiation-induced dermatitis; radiotherapy.

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Figures

FIGURE 1
FIGURE 1
Mean grade of dermatitis, weeks 2–6 of radiotherapy and weeks 2 and 4 after radiotherapy, with and without Aloe vera.
See this image and copyright information in PMC

References

    1. Ryan JL. Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol. 2012;132:985–93. doi: 10.1038/jid.2011.411. - DOI - PMC - PubMed
    1. Hymes SR, Strom EA, Fife C. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol. 2006;54:28–46. doi: 10.1016/j.jaad.2005.08.054. - DOI - PubMed
    1. Richardson J, Smith JE, McIntyre M, Thomas R, Pilkington K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Clin Oncol (R Coll Radiol) 2005;17:478–84. doi: 10.1016/j.clon.2005.04.013. - DOI - PubMed
    1. Bolderston A, Lloyd NS, Wong RK, Holden L, Robb–Blenderman L, on behalf of the Supportive Care Guidelines Group of Cancer Care Ontario’s Program in Evidence-Based Care The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline. Support Care Cancer. 2006;14:802–17. doi: 10.1007/s00520-006-0063-4. - DOI - PubMed
    1. Fotouhi M, Samee F, Amoozegar Hashemi F, Haddad P, Meysami AP. Topical Calendula and betamethasone valerate in prevention of acute radiation dermatitis: a randomized prospective trial [Persian] Tehran Univ Med J. 2007;65:23–9. doi: 10.1016/S0140-6736(11)60236-5. - DOI - PubMed