Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct;50(10):974-82.
doi: 10.1111/psyp.12081. Epub 2013 Aug 2.

P300 amplitude reduction is associated with early-onset and late-onset pathological substance use in a prospectively studied cohort of 14-year-old adolescents

Greg Perlman  1 , Abraham Markin  2 , William G Iacono  1
Affiliations

P300 amplitude reduction is associated with early-onset and late-onset pathological substance use in a prospectively studied cohort of 14-year-old adolescents

Greg Perlman et al. Psychophysiology. 2013 Oct.

Abstract

P3 amplitude reduction (P3AR) is associated with risk for adolescent-onset pathological substance use (PSU). In this longitudinal study, data from over 1,100 adolescent twins were used to examine P3AR in relation to early adolescent onset PSU (i.e., by age 14), late adolescent onset PSU (i.e., ages 14-18), misuse of different classes of substances (PSU-nicotine, PSU-alcohol, PSU-illicit), degree of PSU comorbidity, and gender differences. P3 amplitude was recorded at age 14 from two midline electrodes during a visual oddball paradigm. PSU was defined as meeting criteria for any symptom of a substance use disorder assessed using semistructured clinical interviews. P3AR was associated with degree of drug class comorbidity, early adolescent onset PSU for all three substance classes, and late adolescent onset PSU for alcohol and illicit PSU. Gender differences in P3AR were not statistically significant. These findings provide further evidence that P3AR indexes a nonspecific diathesis for adolescent-onset PSU.

Keywords: Children/Infants; EEG/ERP; Individual differences.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Event-related potential grand means recorded at age 14 by PSU group for PZ (top) and FZ (bottom) by Diagnostic Group.
Figure 2
Figure 2
Event-related potential grand means recorded at age 14 by PSU group for PZ (top) and FZ (bottom) by Comorbidity
See this image and copyright information in PMC

References

    1. Anokhin AP, Vedeniapin AB, et al. The P300 brain potential is reduced in smokers. Psychopharmacology (Berl) 2000;149(4):409–413. - PubMed
    1. Bauer LO. Frontal P300 decrements, childhood conduct disorder, family history, and the prediction of relapse among abstinent cocaine abusers. Drug Alcohol Depend. 1997;44(1):1–10. - PubMed
    1. Begleiter H, Porjesz B, et al. Event-related brain potentials in boys at risk for alcoholism. Science. 1984;225(4669):1493–1496. - PubMed
    1. Berman SM, Whipple SC, et al. P3 in young boys as a predictor of adolescent substance use. Alcohol. 1993;10(1):69–76. - PubMed
    1. Blazei RW, Iacono WG, et al. Father-child transmission of antisocial behavior: the moderating role of father’s presence in the home. J Am Acad Child Adolesc Psychiatry. 2008;47(4):406–415. - PubMed

Publication types

LinkOut - more resources