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Editorial
. 2013 Aug 15;12(16):2524-5.
doi: 10.4161/cc.25835. Epub 2013 Jul 30.

mTOR, AMBRA1, and autophagy: an intricate relationship

Francesca Nazio, Francesco Cecconi
Editorial

mTOR, AMBRA1, and autophagy: an intricate relationship

Francesca Nazio et al. Cell Cycle. .
No abstract available

Keywords: AMBRA1; TFEB; ULK1; lysosome; ubiquitylation.

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Figures

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Figure 1. mTORC1 mediated-signaling during nutrient-rich and nutrient-starvation conditions. (A) In nutrient-rich conditions, mTORC1 phosphorylates S6K1 and 4E-BP1, which regulate cell growth and protein translation. In addition, mTORC1 mediated-phosphorylation (P) on ULK1 complex, AMBRA1, DAP1 and TFEB inhibits autophagy induction. (B) In starvation conditions, mTORC1 is inactive, leading to the activation of ULK1. This, in turn, phosphorylates ATG13, FiP200, AMBRA1, and BECLIN 1, resulting in autophagy induction. This process is also mediated by a TRAF6-dependent ubiquitylation (U) of a few targets. On the other hand, DAP1 and TFEB are activated by dephosphorylation. The putative phosphatases involved in this activity are still unknown.
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References

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