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Editorial
. 2013 Aug 15;12(16):2526-7.
doi: 10.4161/cc.25836. Epub 2013 Jul 29.

γH2AX spreading linked to homology search

Jörg Renkawitz, Claudio A Lademann, Stefan Jentsch
Editorial

γH2AX spreading linked to homology search

Jörg Renkawitz et al. Cell Cycle. .
No abstract available

Keywords: DNA repair; DSB; centromere; chromatin; chromosomal architecture; histone modification; homology search; nuclear organization; γH2A; γH2AX.

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Figures

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Figure 1. γH2AX follows homology search. Homology search (depicted as black arrows) during homologous recombination can be monitored in vivo by Rad51-directed chromatin immunoprecipitations (ChIP). The profiles of ChIP signal distributions for γH2A (orange) and Rad51 (black) both follow homology search and only differ near the DSB because of histone eviction linked to resection (blue, ssDNA).
See this image and copyright information in PMC

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References

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