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Comment
. 2013 Aug;15(8):885-7.
doi: 10.1038/ncb2817.

Linking HSCs to their youth

Eric M Pietras, Emmanuelle Passegué
Comment

Linking HSCs to their youth

Eric M Pietras et al. Nat Cell Biol. 2013 Aug.

Erratum in

  • Nat Cell Biol. 2013 Sep;15(9):1131

Abstract

Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.

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References

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