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Comment
. 2013 Aug;15(8):887-9.
doi: 10.1038/ncb2811.

Transmitting senescence to the cell neighbourhood

Matthew Hoare  1 , Masashi Narita
Affiliations
Comment

Transmitting senescence to the cell neighbourhood

Matthew Hoare et al. Nat Cell Biol. 2013 Aug.

Abstract

Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.

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Comment on

  • A complex secretory program orchestrated by the inflammasome controls paracrine senescence.
    Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J. Acosta JC, et al. Nat Cell Biol. 2013 Aug;15(8):978-90. doi: 10.1038/ncb2784. Epub 2013 Jun 16. Nat Cell Biol. 2013. PMID: 23770676 Free PMC article.

References

    1. Nature. 2012 Jan 18;481(7381):278-86 - PubMed
    1. Nature. 2011 Nov 09;479(7374):547-51 - PubMed
    1. Nat Rev Cancer. 2009 Feb;9(2):81-94 - PubMed
    1. PLoS Biol. 2008 Dec 2;6(12):2853-68 - PubMed
    1. Cell. 2008 Jun 13;133(6):1006-18 - PubMed

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