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Review
. 2013 Aug;54(8):1171-4.
doi: 10.2967/jnumed.113.126086.

Designing the magic bullet? The advancement of immuno-PET into clinical use

Brian D Wright  1 , Suzanne E Lapi
Affiliations
Free article
Review

Designing the magic bullet? The advancement of immuno-PET into clinical use

Brian D Wright et al. J Nucl Med. 2013 Aug.
Free article

Abstract

The development of noninvasive imaging techniques using monoclonal antibodies (mAbs) is a quickly evolving field. Immuno-PET uses positron-emitting isotopes to track the localization of mAbs with excellent image quality. Procedures for labeling mAbs with (89)Zr or (124)I using good manufacturing procedures have been established, and therefore these radiopharmaceuticals are being investigated for clinical use. This short review will focus on immuno-PET with full mAbs using long-lived positron-emitting isotopes ((89)Zr and (124)I) over the past 5 y and discuss their progress into clinical use.

Keywords: 124I; 89Zr; PET; immuno-PET; positron.

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