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Review
. 2013 Aug;13(4):400-3.
doi: 10.7861/clinmedicine.13-4-400.

Treatment of hyperuricaemia and gout

Edward Roddy  1 , Michael Doherty
Affiliations
Review

Treatment of hyperuricaemia and gout

Edward Roddy et al. Clin Med (Lond). 2013 Aug.
No abstract available

Keywords: Hyperuricaemia; allopurinol; colchicine; gout; therapeutics.

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Figures

Fig 1.
Fig 1.
Tophaceous deposits overlying the interphalangeal joints. Note the asymmetrical swelling and yellow-white discoloration of the joints.
Fig 2.
Fig 2.
Simplified purine metabolism showing sites of action of urate-lowering agents.
Fig 3.
Fig 3.
Schematic representation of the detection of monosodium urate (MSU) crystals by the NLRP3 inflammasome. This results in activation of the enzyme caspase 1 and subsequent secretion of ILIL-1β. IL-1β = interleukin 1β; NLRP3 = NLR family, pyrin domain-containing 3; MSU = monosodium urate.
See this image and copyright information in PMC

References

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    1. Schlesinger N, Detry MA, Holland BK, et al. Local ice therapy during bouts of acute gouty arthritis. J Rheumatol 2002;29:331–4. - PubMed
    1. Zhang W, Doherty M, Bardin T, et al. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2006;65:1312–24.10.1136/ard.2006.055269 - DOI - PMC - PubMed
    1. Jordan KM, Cameron JS, Snaith M, et al. British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of gout. Rheumatology 2007;46:1372–4.10.1093/rheumatology/kem056a - DOI - PubMed
    1. Ahern MJ, Reid C, Gordon TP, et al. Does colchicine work? The results of the first controlled study in acute gout. Aust N Z J Med 1987;17:301–4.10.1111/j.1445-5994.1987.tb01232.x - DOI - PubMed