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. 2013 Jul 25;4(3):e0015.
doi: 10.5041/RMMJ.10115. Print 2013 Jul.

Mitral transcatheter technologies

Affiliations

Mitral transcatheter technologies

Francesco Maisano et al. Rambam Maimonides Med J. .

Abstract

Mitral valve regurgitation (MR) is often diagnosed in patients with heart failure and is associated with worsening of symptoms and reduced survival. While surgery remains the gold standard treatment in low-risk patients with degenerative MR, in high-risk patients and in those with functional MR, transcatheter procedures are emerging as an alternative therapeutic option. MitraClip(®) is the device with which the largest clinical experience has been gained to date, as it offers sustained clinical benefit in selected patients. Further to MitraClip implantation, several additional approaches are developing, to better match with the extreme variability of mitral valve disease. Not only repair is evolving, initial steps towards percutaneous mitral valve implantation have already been undertaken, and initial clinical experience has just started.

Keywords: Mitral regurgitation; mitral valve; percutaneous; valve repair; valve replacement.

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Figures

Figure 1
Figure 1
MitraClip® System. A and B: The delivery system in use from lateral and above views, in a live case. C: Fluoroscopic view. D: Echo-view during grasping.
Figure 2
Figure 2
The V-Chordal Device, a Surgically Implantable Adjustable Chordae Device. The device can be implanted with a sutureless approach, which opens the perspective of fully percutaneous implants. The length of the chordae can be adjusted on the beating heart for optimal coaptation. A: A drawing depicting the concept. B: An animal model post-mortem examination showing the adjusting device in the tip of the papillary muscle with chordae attached on the free edge of the anterior leaflet.
Figure 3
Figure 3
Coronary Sinus Annuloplasty: the CARILLON Concept. The Carillon device is composed of a nitinol bar with two anchors. The device is implanted in the coronary sinus to foreshorten the adjacent mitral annulus.
Figure 4
Figure 4
The Direct Annuloplasty Cardioband System in a Patient Immediately after Implantation. The device closely reproduces a surgical annuloplasty band, but is implanted percutaneously, with a transseptal approach.
Figure 5
Figure 5
Perivalvular Leak Closure with the Amplatzer AVPIII Device. This 3D image shows a vascular plug implanted in a lateral leak of the mitral valve. The role of echo imaging is of paramount importance in this field.
Figure 6
Figure 6
The Cardiovalve (Valtech-cardio). A: The Cardiovalve in situ in an animal model, with no perivalvular regurgitation and optimal competence of the valve. B: A 3D view of deployment. C: A 3D view from the atrial perspective of the implanted Cardiovalve.
Figure 7
Figure 7
Valve-in-ring Procedure. Fluoroscopic image of Edwards SAPIEN XT 26 deployment into a previously implanted C-E Physio ring 28.

References

    1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368:1005–11. doi: 10.1016/S0140-6736(06)69208-8. - DOI - PubMed
    1. Dion R. Ischemic mitral regurgitation: when and how should it be corrected? J Heart Valve Dis. 1993;2:536–43. - PubMed
    1. Ling LH, Enriquez-Sarano M, Seward JB, et al. Clinical outcome of mitral regurgitation due to flail leaflet. N Engl J Med. 1996;335:1417–23. doi: 10.1056/NEJM199611073351902. - DOI - PubMed
    1. Gammie JS, Sheng S, Griffith BP, et al. Trends in mitral valve surgery in the United States: results from the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Ann Thorac Surg. 2009;87(5):1431–7. doi: 10.1016/j.athoracsur.2009.01.064. - DOI - PubMed
    1. Detaint D, Sundt TM, Nkomo VT, et al. Surgical correction of mitral regurgitation in the elderly: out-comes and recent improvements. Circulation. 2006;114:265–72. doi: 10.1161/CIRCULATIONAHA.106.619239. - DOI - PubMed