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. 2013 Aug 16;15(16):4214-7.
doi: 10.1021/ol4019419. Epub 2013 Aug 2.

Direct transformation of amides into α-amino phosphonates via a reductive phosphination process

Yuzhen Gao  1 , Zhongbin Huang, Rongqiang Zhuang, Jian Xu, Pengbo Zhang, Guo Tang, Yufen Zhao
Affiliations

Direct transformation of amides into α-amino phosphonates via a reductive phosphination process

Yuzhen Gao et al. Org Lett. .

Abstract

The first general method for the reductive phosphination of amides in one pot has been developed. The reactions described provide a novel access to α-amino phosphonates in good to excellent yields, cover a broad scope of substrates such as secondary and tertiary amides, and do not require a low temperature.

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