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. 2013 Nov;15(11):1214-9.
doi: 10.1080/10286020.2013.820712. Epub 2013 Aug 5.

Lanostane triterpenoids with cytotoxic activities from the fruiting bodies of Ganoderma hainanense

Qing-Yun Ma  1 , Ying Luo, Sheng-Zhuo Huang, Zhi-Kai Guo, Hao-Fu Dai, You-Xing Zhao
Affiliations

Lanostane triterpenoids with cytotoxic activities from the fruiting bodies of Ganoderma hainanense

Qing-Yun Ma et al. J Asian Nat Prod Res. 2013 Nov.

Abstract

Twelve lanostane triterpenoids (1-12) including a new one 16α,26-dihydroxylanosta-8,24-dien-3-one (1) were isolated from the fruiting bodies of Ganoderma hainanense. The structure of the new compound was elucidated by 1D and 2D NMR and MS spectroscopic analyses. All isolates were evaluated for their cytotoxicities against human tumor cell lines K-562, SMMC-7721, and SGC-7901 and five compounds (1, 2, 5,7, and 9) showed definite cytotoxicities against K-562 cell line. Meanwhile, compounds 2, 5,7, and 9 exhibited cytotoxic activities against SMMC-7721 and SGC-7901 cell lines.

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