Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Aug 1;13(2):139-40.
doi: 10.1016/j.stem.2013.07.014.

Transplantable liver organoids made from only three ingredients

Holger Willenbring  1 , Alejandro Soto-Gutierrez
Affiliations
Comment

Transplantable liver organoids made from only three ingredients

Holger Willenbring et al. Cell Stem Cell. .

Abstract

Liver cell therapies using induced pluripotent stem cells (iPSCs) are in development. A recent paper in Nature by Takebe et al. expands the range of liver diseases that could be treated with iPSC-derived hepatocytes by combining them with endothelial and stromal cells to generate organoids that survive and function extrahepatically.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Transplantation of liver organoids into extra hepatic sites such as the mesentery as a potential therapy for liver cirrhosis. Arteries are shown in red, veins in blue, and biliary structures in green. Only the veins of the mesentery are shown.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M. Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice. Nat Biotechnol. 2007;25:903–910. - PMC - PubMed
    1. Gruenloh W, Kambal A, Sondergaard C, McGee J, Nacey C, Kalomoiris S, Pepper K, Olson S, Fierro F, Nolta JA. Characterization and in vivo testing of mesenchymal stem cells derived from human embryonic stem cells. Tissue Eng Part A. 2011;17:1517–1525. - PMC - PubMed
    1. Hoppo T, Komori J, Manohar R, Stolz DB, Lagasse E. Rescue of lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology. 2011;140:656–666. e652. - PMC - PubMed
    1. Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK. Tissue engineering: creation of long-lasting blood vessels. Nature. 2004;428:138–139. - PubMed
    1. Liu L, Yannam GR, Nishikawa T, Yamamoto T, Basma H, Ito R, Nagaya M, Dutta-Moscato J, Stolz DB, Duan F, et al. The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology. 2012;55:1529–1539. - PMC - PubMed

Publication types