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. 2013 Aug 3;2013(8):CD009952.
doi: 10.1002/14651858.CD009952.pub2.

Transabdominal amnioinfusion for improving fetal outcomes after oligohydramnios secondary to preterm prelabour rupture of membranes before 26 weeks

Stijn Van Teeffelen  1 , Eva Pajkrt, Christine Willekes, Sander M J Van Kuijk, Ben Willem J Mol
Affiliations

Transabdominal amnioinfusion for improving fetal outcomes after oligohydramnios secondary to preterm prelabour rupture of membranes before 26 weeks

Stijn Van Teeffelen et al. Cochrane Database Syst Rev. .

Abstract

Background: Preterm prelabour rupture of membranes (PPROM) before 26 weeks can delay lung development and can cause pulmonary hypoplasia, as a result of oligohydramnios. Restoring the amniotic fluid volume by transabdominal amnioinfusion might prevent abnormal lung development and might have a protective effect for neurological complications, fetal deformities and neonatal sepsis.

Objectives: To assess the effectiveness of transabdominal amnioinfusion in improving perinatal outcome in women with oligohydramnios secondary to rupture of fetal membranes before 26 weeks.

Search methods: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 April 2013).

Selection criteria: All randomised controlled trials comparing transabdominal amnioinfusion with no transabdominal amnioinfusion. Cluster- or quasi-randomised trials were not eligible for inclusion. In cases where only an abstract was available, we attempted to find the full articles.

Data collection and analysis: Two review authors assessed trials for inclusion. No eligible trials were identified.

Main results: There are no included studies.

Authors' conclusions: There is currently no evidence to evaluate the use of transabdominal amnioinfusion in women with oligohydramnios secondary to rupture of fetal membranes before 26 weeks for improving perinatal outcome. Further research examining the effects of this intervention is needed. Two randomised controlled trials are ongoing but final data have not yet been published.

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Conflict of interest statement

None known.

Update of

References

References to studies excluded from this review

    1. Santis M, Scavo M, Noia G, Masini L, Piersigilli F, Romagnoli C, et al. Transabdominal amnioinfusion treatment of severe oligohydramnios in preterm premature rupture of membranes at less than 26 gestational weeks. Fetal Diagnosis and Therapy 2003;18(6):412‐7. - PubMed
    1. Gonzalez R, Malde J, Carrillo MP, Sancho‐Minano J, Garrote A, Munoz A, et al. The use of amnioinfusion in preterm deliveries. Preliminary results [abstract]. Journal of Perinatal Medicine 2001;29 Suppl 1(Pt 2):629.
    1. Gowri R, Soundararaghavan S. Evaluation of transabdominal amnioinfusion in the antepartum management of oligohydramnios complicating preterm pregnancies. Journal of Obstetrics and Gynecology of India 2004;54(5):460‐3.
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References to ongoing studies

    1. Locatelli A. Open randomized trial comparing perinatal outcome following expectant management versus amnioinfusion in PPROM <25 wks with persistent oligohydramnios. http://clinicaltrials.gov/ct2/show/record/NCT00787163 (accessed 6 July 2...2008.
    1. Roberts D, Alfirevic Z, Bricker L, Beardsmore C, Paturi P, Taylor S, et al. Amnioinfusion in preterm premature rupture of membranes (AMIPROM study). Current Controlled Trials (www.controlled‐trials.com/) (accessed 23 March 2009).
    2. Roberts D, Beardsmore C, Shaw B, Martin W, Vause S, Bricker L, et al. AMIPROM: a pilot RCT on serial transabdominal amnioinfusion versus expectant management in very early PROM. Ultrasound in Obstetrics & Gynecology 2012;40(Suppl 1):80.

Additional references

    1. Chin TW, Natarajan G, Abdulhamid I. Pediatric pulmonary hypoplasia treatment and management. http://emedicine.medscape.com/article/1005696‐treatment (accessed 2012)2009.
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    1. Gramellini D, Fieni S, Kaihura C, Piantelli G, Verrotti C. Antepartum amnioinfusion: a review. Journal of Maternal‐Fetal & Neonatal Medicine 2003;14(5):291‐6. - PubMed
    1. Hadi HA, Hodson CA, Strickland D. Premature rupture of the membranes between 20 and 25 weeks' gestation: role of amniotic fluid volume in perinatal outcome. American Journal of Obstetrics and Gynecology 1994;170(4):1139‐44. - PubMed
    1. Harbord RM, Egger M, Sterne JA. A modified test for small‐study effects in meta‐analyses of controlled trials with binary endpoints. Statistics in Medicine 2006;25(20):3443‐57. - PubMed

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