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Review
. 2014 Mar;69(3):315-22.
doi: 10.1093/gerona/glt109. Epub 2013 Aug 2.

Aging and chronic kidney disease: the impact on physical function and cognition

Shuchi Anand  1 , Kirsten L Johansen, Manjula Kurella Tamura
Affiliations
Review

Aging and chronic kidney disease: the impact on physical function and cognition

Shuchi Anand et al. J Gerontol A Biol Sci Med Sci. 2014 Mar.

Abstract

Evidence has recently been building that the presence of chronic kidney disease (CKD) is an independent contributor to decline in physical and cognitive functions in older adults. CKD affects 45% of persons older than 70 years of age and can double the risk for physical impairment, cognitive dysfunction, and frailty. To increase awareness of this relatively new concept of CKD as a risk factor for accelerated aging, we review studies on the association of CKD with physical function, frailty, and cognitive function. We also present a summary of the proposed mechanisms for these associations.

Keywords: Chronic kidney disease; Cognitive function.; Frailty; Physical function.

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Figures

Figure 1.
Figure 1.
Conceptual model linking chronic kidney disease (CKD) with decline in physical function and cognition. Small vessel disease is likely a shared risk factor for CKD and cognitive decline as well as physical function decline, and CKD may also play a direct role in accelerating these processes.
See this image and copyright information in PMC

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