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Case Reports
. 2013 Apr;4(2):188-90.
doi: 10.4103/0976-3147.112763.

Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis

Indranil Chakrabarti  1 , Nilanjana Ghosh, Amita Giri
Affiliations
Case Reports

Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis

Indranil Chakrabarti et al. J Neurosci Rural Pract. 2013 Apr.

Abstract

Primary sarcoma of breast are rare. Diagnosis by aspiration cytology is difficult due to nonspecific cytomorphologic features. An initial presentation with neurological symptoms due to metastasis of breast sarcoma to the brain has not been previously reported. Here, we describe a case of a 60-year-old female who presented with headache, dizziness and convulsion and was subsequently diagnosed with undifferentiated high grade pleomorphic sarcoma of breast with cerebellar metastasis.

Keywords: Aspiration cytology; breast sarcoma; cerebellar metastasis; pleomorphic malignant fibrous histiocytoma; undifferentiated high grade pleomorphic sarcoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
CT scan showing a heterogeneously enhancing hypodense infratentorial lesion in left cerebellar hemisphere and vermis compressing and displacing the fourth ventricle
Figure 2
Figure 2
Microphotograph showing dispersed population and loose aggregates of pleomorphic spindle cells with bizarre cells. Inset shows a multinucleated giant cell (white arrow). (Papanicolaou stain; ×400 magnification)
Figure 3
Figure 3
Microphotograph showing histopathology of undifferentiated pleomorphic sarcoma of breast with inset in lower right showing foci of dystrophic calcification (H and E, ×100 magnification) Inset in upper left shows atypical mitotic figure (H and E, ×400 magnification)
See this image and copyright information in PMC

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