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. 2012 Dec 1;16(6):323-332.
doi: 10.1016/j.cossms.2013.01.001.

Polymeric Nanomedicines Based on Poly(lactide) and Poly(lactide-co-glycolide)

Rong Tong  1 , Nathan P Gabrielson, Timothy M Fan, Jianjun Cheng
Affiliations

Polymeric Nanomedicines Based on Poly(lactide) and Poly(lactide-co-glycolide)

Rong Tong et al. Curr Opin Solid State Mater Sci. .

Abstract

Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer-drug conjugates and nanoconjugates.

Keywords: Cancer; PLA; PLGA; aptamer; cancer targeting; chemotherapeutics; drug delivery; nanoconjugates; nanomedicine; poly(lactide); poly(lactide-co-glycolide); polymer-drug conjugates.

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Figures

Figure 1
Figure 1
Schematic illustration of `Enhanced Permeability and Retention' (EPR) effect
Figure 2
Figure 2
(a) Schematic illustration of LA, GA, PLA and PLGA; (b) scheme of PLGA hydrolysis
Figure 3
Figure 3
Scheme of the synthesis of TGPS-PLA
Figure 4
Figure 4
(a) Scheme of the synthesis of Doxo-PLGA; (b) the chemical structure of combrestatin A4
Figure 5
Figure 5
Synthesis of mPEG-PLA-TNP-470 (Lodamin)
Figure 6
Figure 6
PLA polymerization initiated by cholesterol catalyzed by AlEt3
Figure 7
Figure 7
(a) Synthesis of PLA-Ptxl nanoconjugates with regioselectivity; (b) structures of (BDI-X)ZnN(TMS)2 catalyst; (c) scheme of Ptxl-LAn reduction to confirm the regioselective conjugation of PLA onto Ptxl; (d) Drugs and dyes can be incorporated to PLA to form nanoconjugates. The hydroxyl group highlighted by the red color in (d) indicated the PLA conjugation site of the molecule.
Figure 8
Figure 8
Regioselective reaction of Doxo and succinic acid, mediated by (BDI-II)ZnN(TMS)2, to yield Doxo-14-SE.
Figure 9
Figure 9
Schematic illustration of aptamer-nanoparticles targeting strategy
See this image and copyright information in PMC

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