Why does pandemic influenza virus kill?
- PMID: 23916382
- PMCID: PMC3791683
- DOI: 10.1016/j.ajpath.2013.06.020
Why does pandemic influenza virus kill?
Abstract
This Commentary highlights the article by Gao et al, which showed protracted viral replication and correlated viral load with illness duration and proinflammatory cytokine levels in lung tissue samples from 2009 H1N1 victims.
Comment on
-
Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): role of the host immune response in pathogenesis.Am J Pathol. 2013 Oct;183(4):1258-1268. doi: 10.1016/j.ajpath.2013.06.023. Epub 2013 Aug 11. Am J Pathol. 2013. PMID: 23938324 Free PMC article.
References
-
- Gao R., Bhatnagar J., Blau D., Greer P., Rollin D.C., Denison A.M., Deleon-Carnes M., Shieh W.J., Sambhara S., Tumpey T.M., Patel M., Liu L., Paddock C., Drew C., Shu Y., Katz J.M., Zaki S.R. Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): role of the host immune response in pathogenesis. Am J Pathol. 2013;183:1258–1268. - PMC - PubMed
-
- Jain S., Kamimoto L., Bramley A.M., Schmitz A.M., Benoit S.R., Louie J., Sugerman D.E., Druckenmiller J.K., Ritger K.A., Chugh R., Jasuja S., Deutscher M., Chen S., Walker J.D., Duchin J.S., Lett S., Soliva S., Wells E.V., Swerdlow D., Uyeki T.M., Fiore A.E., Olsen S.J., Fry A.M., Bridges C.B., Finelli L., 2009 Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med. 2009;361:1935–1944. - PubMed
-
- Paquette S.G., Banner D., Zhao Z., Fang Y., Huang S.S., Leomicronn A.J., Ng D.C., Almansa R., Martin-Loeches I., Ramirez P., Socias L., Loza A., Blanco J., Sansonetti P., Rello J., Andaluz D., Shum B., Rubino S., de Lejarazu R.O., Tran D., Delogu G., Fadda G., Krajden S., Rubin B.B., Bermejo-Martin J.F., Kelvin A.A., Kelvin D.J. Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection. PLoS One. 2012;7:e38214. - PMC - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
