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. 2013 Aug 2;11(8):2713-21.
doi: 10.3390/md11082713.

Two novel tyrosinase inhibitory sesquiterpenes induced by CuCl2 from a marine-derived fungus Pestalotiopsis sp. Z233

Bin Wu  1 , Xiaodan Wu, Min Sun, Minhui Li
Affiliations

Two novel tyrosinase inhibitory sesquiterpenes induced by CuCl2 from a marine-derived fungus Pestalotiopsis sp. Z233

Bin Wu et al. Mar Drugs. .

Abstract

Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl2. Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC50 value of 14.8 µM and 22.3 µM.

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Figures

Figure 1
Figure 1
Key 1H 1H COSY and HMBC correlations of compounds 1 and 2.
Figure 2
Figure 2
Structures of compounds 1 and 2.
See this image and copyright information in PMC

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