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. 2014 Jan;59(1):57-63.
doi: 10.1007/s10620-013-2804-9. Epub 2013 Aug 6.

Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus

Dongren Ren  1 , Gaolin Zheng, Susan Bream, Whitney Tevebaugh, Nicholas J Shaheen, Xiaoxin Chen
Affiliations

Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus

Dongren Ren et al. Dig Dis Sci. 2014 Jan.

Abstract

Background: Barrett's esophagus (BE), the premalignant lesion of esophageal adenocarcinoma, is believed to develop as a result of chronic gastroesophageal reflux disease (GERD). Approximately 10 % of subjects with GERD progress to BE. Genetic, epigenetic and other risk factors may contribute to this inter-individual variability. Caudal type homeobox 1 (Cdx1) and Caudal type homeobox 2 (Cdx2) play important regulatory roles in the development of human BE.

Aims: To determine associations between Cdx1 and Cdx2 single nucleotide polymorphisms (SNPs) and BE.

Methods: Genomic DNA was extracted from blood samples collected from BE (n = 109) and GERD (n = 223) patients for genotyping of 5 SNPs each of Cdx1 and Cdx2 using TaqMan allelic discrimination assays. Odds ratios and 95 % confidence intervals of SNPs and haplotypes were calculated with a logistic regression model adjusted for factors including age, sex and hiatal hernia. Interactions between genetic variants and these three risk factors were also analyzed.

Results: Older age (≥50 years), male sex and hiatal hernia were significantly associated with BE (P < 0.001). Five variants of Cdx1 SNPs (rs3776082, rs717746 and rs3776083), one Cdx1 haplotype, and three variants of Cdx2 SNPs (rs4769585 and rs3812863) were associated with BE (P < 0.05). Statistically significant interactions were detected between most of these SNPs and the three risk factors (P < 0.05).

Conclusion: Certain SNPs of Cdx1 and Cdx2 and their interactions with other risk factors are associated with BE, and may contribute to human susceptibility to BE.

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Conflict of interest statement

Conflict of interest: None

Comment in

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