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. 2013 Aug 16;15(16):4178-81.
doi: 10.1021/ol4018744. Epub 2013 Aug 7.

A method for the net contra-thermodynamic isomerization of cyclic trisubstituted alkenes

Raphaël F Guignard  1 , Laurent Petit, Samir Z Zard
Affiliations

A method for the net contra-thermodynamic isomerization of cyclic trisubstituted alkenes

Raphaël F Guignard et al. Org Lett. .

Abstract

A simple sequence for the net contra-thermodynamic isomerization of cyclic trisubstituted alkenes is reported consisting of a radical addition of p-chlorothiophenol, followed by oxidation to the sulfoxide and thermal syn-elimination to give the least substituted isomeric cycloalkene.

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