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. 2013 Sep 28;49(75):8338-40.
doi: 10.1039/c3cc44866e.

Light-inducible activation of target mRNA translation in mammalian cells

Jicong Cao  1 , Manish Arha, Chaitanya Sudrik, Lukasz J Bugaj, David V Schaffer, Ravi S Kane
Affiliations

Light-inducible activation of target mRNA translation in mammalian cells

Jicong Cao et al. Chem Commun (Camb). .

Abstract

A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.

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