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. 2013 Sep 25;49(74):8193-5.
doi: 10.1039/c3cc44046j.

Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines

Abdul Karim Haji Dheere  1 , Nadiya Yusuf, Antony Gee
Affiliations

Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines

Abdul Karim Haji Dheere et al. Chem Commun (Camb). .

Abstract

A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.

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