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Comment
. 2013 Aug 7;5(197):197fs31.
doi: 10.1126/scitranslmed.3006810.

Genomics traces carcinogen fingerprints

William Lee  1 , Marc Ladanyi
Affiliations
Comment

Genomics traces carcinogen fingerprints

William Lee et al. Sci Transl Med. .

Abstract

Genome-wide sequencing highlights the distinctive pattern of mutations caused by a plant that contains a potent carcinogen.

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  • Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.
    Poon SL, Pang ST, McPherson JR, Yu W, Huang KK, Guan P, Weng WH, Siew EY, Liu Y, Heng HL, Chong SC, Gan A, Tay ST, Lim WK, Cutcutache I, Huang D, Ler LD, Nairismägi ML, Lee MH, Chang YH, Yu KJ, Chan-On W, Li BK, Yuan YF, Qian CN, Ng KF, Wu CF, Hsu CL, Bunte RM, Stratton MR, Futreal PA, Sung WK, Chuang CK, Ong CK, Rozen SG, Tan P, Teh BT. Poon SL, et al. Sci Transl Med. 2013 Aug 7;5(197):197ra101. doi: 10.1126/scitranslmed.3006086. Sci Transl Med. 2013. PMID: 23926199
  • Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing.
    Hoang ML, Chen CH, Sidorenko VS, He J, Dickman KG, Yun BH, Moriya M, Niknafs N, Douville C, Karchin R, Turesky RJ, Pu YS, Vogelstein B, Papadopoulos N, Grollman AP, Kinzler KW, Rosenquist TA. Hoang ML, et al. Sci Transl Med. 2013 Aug 7;5(197):197ra102. doi: 10.1126/scitranslmed.3006200. Sci Transl Med. 2013. PMID: 23926200 Free PMC article.

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