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. 2013 Jan;14(1):3-7.

The Concepts and Consequences of Early Ovarian Ageing: A Caveat to Women's Health

Panda Subrat  1 , Singh A Santa, Jha Vandana
Affiliations

The Concepts and Consequences of Early Ovarian Ageing: A Caveat to Women's Health

Panda Subrat et al. J Reprod Infertil. 2013 Jan.

Abstract

Apparent rise in the incidence of infertility in females and the trend shifting towards delayed child bearing brought up the concept of ovarian ageing. Women in their early thirties show poor ovarian reserve which is an entity named as early ovarian ageing. Early ovarian ageing is mostly genetically determined, but acquired modifiable factors like smoking, or ovarian surgery have some roles. Infertility and subfertility are the only clinical recognizable sequelae in the early ovarian ageing. The worrisome fact is that the outcome of assisted reproductive techniques is also not that much encouraging. Even if ovarian priming with DHEA has raised hope in the assisted reproductive techniques for these patients, but more randomized trials are needed to support this. Screening of these women with antimullerian hormone, antral follicle count and genetic analysis may be useful for recommendation at appropriate biological time regarding conception or fertility preservation.

Keywords: Assisted reproductive technologies; Early ovarian ageing; Infertility; Oocytes.

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References

    1. Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod. 1992;7(10):1342–6. - PubMed
    1. Treloar SA, Do KA, Martin NG. Genetic influences on the age at menopause. Lancet. 1998;352(9134):1084–5. - PubMed
    1. Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L, et al. ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26(7):1616–24. - PubMed
    1. Bancsi LF, Broekmans FJ, Eijkemans MJ, de Jong FH, Habbema JD, te Velde ER. Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertil Steril. 2002;77(2):328–36. - PubMed
    1. Broekmans FJ, Scheffer GJ, Bancsi LF, Dorland M, Blankenstein MA, te Velde ER. Ovarian reserve tests in infertility practice and normal fertile women. Maturitas. 1998;30(2):205–14. - PubMed

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