Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2013 Aug 8:13:32.
doi: 10.1186/1472-6874-13-32.

Levonorgestrel releasing intrauterine system (Mirena) versus endometrial ablation (Novasure) in women with heavy menstrual bleeding: a multicentre randomised controlled trial

Malou C Herman, Marian J van den Brink, Peggy M Geomini, Hannah S van Meurs, Judith A Huirne, Heleen P Eising, Anne Timmermans, Johanna M A Pijnenborg, Ellen R Klinkert, Sjors F Coppus, Theodoor E Nieboer, Ruby Catshoek, Lucet F van der Voet, Hugo W F van Eijndhoven, Giuseppe C M Graziosi, Sebastiaan Veersema, Paul J van Kesteren, Josje Langenveld, Nicol A C Smeets, Huib A A M van Vliet, Jan Willem van der Steeg, Yvonne Lisman-van Leeuwen, Janny H Dekker, Ben W Mol, Marjolein Y Berger, Marlies Y Bongers
Randomized Controlled Trial

Levonorgestrel releasing intrauterine system (Mirena) versus endometrial ablation (Novasure) in women with heavy menstrual bleeding: a multicentre randomised controlled trial

Malou C Herman et al. BMC Womens Health. .

Abstract

Background: Heavy menstrual bleeding is an important health problem. Two frequently used therapies are the levonorgestrel intra-uterine system (LNG-IUS) and endometrial ablation. The LNG-IUS can be applied easily by the general practitioner, which saves costs, but has considerable failure rates. As an alternative, endometrial ablation is also very effective, but this treatment has to be performed by a gynaecologist. Due to lack of direct comparison of LNG-IUS with endometrial ablation, there is no evidence based preferred advice for the use of one of these treatment possibilities.

Method/design: A multicenter randomised controlled trial, organised in a network infrastructure in the Netherlands in which general practitioners and gynaecologists collaborate.

Discusson: This study, considering both effectiveness and cost effectiveness of LNG-IUS versus endometrial ablation may well improve care for women with heavy menstrual bleeding.

Trial registration: Dutch trial register, number NTR2984.

PubMed Disclaimer

References

    1. Palep-Singh M, Prentice A. Epidemiology of abnormal uterine bleeding. Best Pract Res Clin Obstet Gynaecol. 2007;21(6):887–890. doi: 10.1016/j.bpobgyn.2007.03.012. - DOI - PubMed
    1. Shapley M, Jordan K, Croft PR. An epidemiological survey of symptoms of menstrual loss in the community. Br J Gen Pract. 2004;54(502):359–363. - PMC - PubMed
    1. Lethaby AE, Cooke I, Rees M. Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding. Cochrane Database Syst Rev. 2005;4 CD002126. - PubMed
    1. Cooper K, Lee A, Chien P, Raja E, Timmaraju V, Bhattacharya S. Outcomes following hysterectomy or endometrial ablation for heavy menstrual bleeding: Retrospective analysis of hospital episode statistics in scotland. BJOG. 2011;118(10):1171–1179. doi: 10.1111/j.1471-0528.2011.03011.x. - DOI - PubMed
    1. Prismant. Dutch Hospital Data. 2009.

Publication types

Substances

Associated data

LinkOut - more resources