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Comment
. 2013 Aug 5;23(15):R662-5.
doi: 10.1016/j.cub.2013.06.054.

Lineage specification: reading the instructions may help!

Gill May  1 , Tariq Enver
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Lineage specification: reading the instructions may help!

Gill May et al. Curr Biol. .
Free article

Abstract

Understanding lineage specification is biologically important and critical for the production of cells for regenerative medicine. Extrinsic cues are clearly necessary but do they direct or select lineage? Single-cell analysis now suggests that cytokine signaling can instruct lineage choice in blood stem cells.

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