Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug 8;1(4):e00581-13.
doi: 10.1128/genomeA.00581-13.

Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin

Damir Baranasic  1 , Ranko Gacesa, Antonio Starcevic, Jurica Zucko, Marko Blazic, Marinka Horvat, Kresimir Gjuracic, Stefan Fujs, Daslav Hranueli, Gregor Kosec, John Cullum, Hrvoje Petkovic
Affiliations

Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin

Damir Baranasic et al. Genome Announc. .

Abstract

Streptomyces rapamycinicus strain NRRL 5491 produces the important drug rapamycin. It has a large genome of 12.7 Mb, of which over 3 Mb consists of 48 secondary metabolite biosynthesis clusters.

PubMed Disclaimer

References

    1. Kumar Y, Goodfellow M. 2008. Five new members of the Streptomyces violaceusniger 16S rRNA gene clade: Streptomyces castelarensis sp. nov., comb. nov., Streptomyces himastatinicus sp. nov., Streptomyces mordarskii sp. nov., Streptomyces rapamycinicus sp. nov., and Streptomyces ruanii sp. nov. Int. J. Syst. Evol. Microbiol. 58:1369–1378.10.1099/ijs.0.65408-0 - DOI - PubMed
    1. Vézina C, Kudelski A, Sehgal SN. 1975. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28:721–726 - PubMed
    1. Alayev A, Holz MK. 2013. mTOR signaling for biological control and cancer. J. Cell. Physiol. 228:1658–1664 - PMC - PubMed
    1. Groth CG, Bäckman L, Morales JM, Calne R, Kreis H, Lang P, Touraine JL, Claesson K, Campistol JM, Durand D, Wramner L, Brattström C, Charpentier B. 1999. Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study group. Transplantation 67:1036–1042 - PubMed
    1. Slavin L, Chhabra A, Tobis JM. 2007. Drug-eluting stents: preventing restenosis. Cardiol. Rev. 15:1–12 - PubMed