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Comment
. 2013 Aug 9;341(6146):626-7.
doi: 10.1126/science.1242671.

Genetics. The maturing brain methylome

Harrison W Gabel  1 , Michael E Greenberg
Affiliations
Comment

Genetics. The maturing brain methylome

Harrison W Gabel et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1. A distinct neuronal methylome
(A) High mCH and hmCG accumulate in mammalian neurons postnatally, coinciding with the period of active synapse development and maturation. (B) A schematic of the same genomic region in fetal and adult brain shows that mCH builds up in adult neurons and is enriched at repressed genes and enhancers. hmCG associates with active genes and can premark enhancers in the fetal brain that will become demethylated and active in the adult. Differential affinity to hmCG and mCH may alter the binding profile of methyl-DNA binding proteins and thereby control distinct neuronal transcription.
See this image and copyright information in PMC

Comment on

  • Global epigenomic reconfiguration during mammalian brain development.
    Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejnowski TJ, Behrens MM, Ecker JR. Lister R, et al. Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4. Science. 2013. PMID: 23828890 Free PMC article.

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