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. 1990 Sep;47(3):454-8.

Allan-Herndon syndrome. II. Linkage to DNA markers in Xq21

C E Schwartz  1 , J Ulmer, A Brown, I Pancoast, H O Goodman, R E Stevenson
Affiliations

Allan-Herndon syndrome. II. Linkage to DNA markers in Xq21

C E Schwartz et al. Am J Hum Genet. 1990 Sep.

Abstract

The original family with the Allan-Herndon type of X-linked mental retardation has been investigated for linkage by using DNA probes spanning the length of the X chromosome. Available for study, over 3 generations, were 13 affected males, three obligate carriers, and three normal sons of the obligate carriers. Initial disease-to-marker analysis suggested linkage to three markers (DXYS2 [7b], DXS250 [GMGX22], and DXS3 [p19-2]) located in Xq21. All three exhibited the same maximum lod score of 2.3 at a maximum theta of .05. Multipoint analysis using LINKMAP and a set of four DNA markers (DXYS1-DXYS2-DXS3-DXS94) gave a multipoint lod score of 3.58 for a location of the Allan-Herndon syndrome near locus DXYS1 (pDP34). Therefore, our data indicate that the gene for the Allan-Herndon syndrome is likely located in Xq21.

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