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. 2013 Jun 1;4(6):1015-1017.
doi: 10.1039/C3MD00082F.

The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials

Tolulope A Aweda  1 , Oluwatayo Ikotun, Tara Mastren, Carolyn L Cannon, Brian Wright, Wiley J Youngs, Cathy Cutler, James Guthrie, Suzanne E Lapi
Affiliations

The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials

Tolulope A Aweda et al. Medchemcomm. .

Abstract

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies.

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Figures

Fig. 1
Fig. 1
Biodistribution of nebulized [111Ag]SCC1 in normal mice. Two dose delivery approaches; 1 aerosol dose for 5 m and 5 doses administered within 3 days were investigated. No significant difference was observed in the lungs or any organ due to the fast and continuous clearance of the radiotracer. Excretion data (urine and feces) is only given for the 1 dose cohort.
Scheme 1
Scheme 1
Synthesis of SCC1 from caffeine
See this image and copyright information in PMC

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