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. 2013 Dec;12(6):1141-3.
doi: 10.1111/acel.12125. Epub 2013 Aug 12.

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease

Mark W Robinson  1 , Dagmara McGuinness, Rachael Swann, Stephen Barclay, Peter R Mills, Arvind H Patel, John McLauchlan, Paul G Shiels
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Free article

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease

Mark W Robinson et al. Aging Cell. 2013 Dec.
Free article

Abstract

Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as a biomarker of aging (BoA). In this study, we have evaluated CDKN2 locus transcripts as alternative BoAs in C-HC. Our results suggest that C-HC induces non-cell-autonomous senescence and accelerates biological aging. The CDKN2 locus may provide a link between C-HC and increased susceptibility to age-associated diseases and provides novel biomarkers for assessing its impact on aging processes in man.

Keywords: CDKN2 locus; biological aging; chronic HCV infection; telomere length.

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