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Review
. 2014 Jan;141(1):28-36.
doi: 10.1017/S0031182013001017. Epub 2013 Aug 9.

Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter

Ian H Gilbert  1
Affiliations
Free PMC article
Review

Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter

Ian H Gilbert. Parasitology. 2014 Jan.
Free PMC article

Abstract

Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics.

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Figures

Fig. 1.
Fig. 1.
Current drugs used for the treatment of kinetoplastid infections.
Fig. 2.
Fig. 2.
Compounds active against T. brucei NMT.
See this image and copyright information in PMC

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