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Comment
. 2013 Aug 6;18(2):151-2.
doi: 10.1016/j.cmet.2013.07.009.

Bile acid look-alike controls life span in C. elegans

Albert K Groen  1 , Folkert Kuipers
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Bile acid look-alike controls life span in C. elegans

Albert K Groen et al. Cell Metab. .
Free article

Abstract

Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the importance of sterol balance for healthy life. Magner et al. (2013) now show that, in C. elegans, the nuclear receptor NHR-8 is key in regulation of cholesterol balance and production of dafachronic acid, a bile acid-like steroid that controls longevity.

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