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Case Reports
. 2013 Nov;163(5):1511-3.
doi: 10.1016/j.jpeds.2013.06.043. Epub 2013 Aug 6.

Breakthrough varicella in a cancer patient with persistent varicella antibody after one varicella vaccination

Masaki Yamada  1 , Natalie Kamberos, Charles Grose
Affiliations
Case Reports

Breakthrough varicella in a cancer patient with persistent varicella antibody after one varicella vaccination

Masaki Yamada et al. J Pediatr. 2013 Nov.

Abstract

A boy with Hodgkin disease contracted breakthrough varicella from his father, who had chickenpox. The boy had received a single varicella vaccination and was seropositive by enzyme-linked immunosorbent assay before being diagnosed with breakthrough varicella. Seropositivity after a single varicella vaccination does not guarantee complete protection in an immunocompromised child.

Keywords: ELISA; Enzyme-linked immunosorbent assay; IV; Intravenous; VZV; Varicella zoster virus.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure
Figure
A, Clinical and virological data from the patient. B, Molecular diagnosis for VZV infection was performed on day 8, because of the unanticipated recurrence of the vesicular exanthem after the first hospitalization. Because of the large number of SNPs within VZV ORF62, a segment of ORF62 was amplified from the VZV-infected white blood cells and its sequence compared with published sequences of European/North American VZV strains (Dumas and 32) as well as the Japanese/Asian Oka strains. The patient’s VZV strain (1202) was not a vaccine strain. IVIG, intravenous immunoglobulin.
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