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. 2013 Sep;21(9):448-50.
doi: 10.1016/j.tim.2013.07.007. Epub 2013 Aug 8.

Insights into ancient leprosy and tuberculosis using metagenomics

Helen D Donoghue  1
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Free article

Insights into ancient leprosy and tuberculosis using metagenomics

Helen D Donoghue. Trends Microbiol. 2013 Sep.
Free article

Abstract

Leprosy and tuberculosis were widespread in the past and remain significant diseases today. Comparison of ancient and modern genomes of Mycobacterium leprae and Mycobacterium tuberculosis gives insight into their evolution and a calibration of the timescale for observed changes. Recently, whole genome sequencing has revealed genotypes and mixed-strain infections.

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