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. 2013 Sep 17;587(18):3069-75.
doi: 10.1016/j.febslet.2013.06.058. Epub 2013 Aug 8.

MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3

Yi Zhang  1 , Qiping Lu, Xun Cai
Affiliations
Free article

MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3

Yi Zhang et al. FEBS Lett. .
Free article

Abstract

Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for gastric cancer (GC). miR-106a, which is highly expressed in GC, influences a variety of aspects of GC. However, the function of miR-106a in MDR of GC still remains unclear. In the present study, we found that miR-106a is elevated in MDR cell lines. miR-106a promotes chemo-resistance of GC cells, accelerates ADR efflux, and suppresses drug-induced apoptosis. Finally, we show that runt-related trans factor 3 (RUNX3) is the functional target of miR-106a. Collectively, these findings demonstrate that miR-106a may promote MDR in GC cells by targeting RUNX3.

Keywords: Gastric cancer; Multidrug resistance; Runt-related transcription factor 3; miR-106a.

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