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Review
. 2013 Dec;56(4):675-82.
doi: 10.1016/j.molimm.2013.05.002. Epub 2013 Aug 8.

GM-CSF as a therapeutic target in inflammatory diseases

Annemarie van Nieuwenhuijze  1 , Marije Koenders, Debbie Roeleveld, Matthew A Sleeman, Wim van den Berg, Ian P Wicks
Affiliations
Review

GM-CSF as a therapeutic target in inflammatory diseases

Annemarie van Nieuwenhuijze et al. Mol Immunol. 2013 Dec.

Abstract

GM-CSF is a well-known haemopoietic growth factor that is used in the clinic to correct neutropaenia, usually as a result of chemotherapy. GM-CSF also has many pro-inflammatory functions and recent data implicates GM-CSF as a key factor in Th17 driven autoimmune inflammatory conditions. In this review we summarize the findings that have led to the development of GM-CSF antagonists for the treatment of autoimmune diseases like rheumatoid arthritis (RA) and discuss some results of recent clinical trials of these agents.

Keywords: Autoimmune disease; Autoimmunity; Cytokines; GM-CSF; GM-CSF receptor; Inflammatory disease; Rheumatoid arthritis; T cells; Th17 pathway.

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