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. 2013 Sep:67:464-8.
doi: 10.1016/j.ejmech.2013.06.056. Epub 2013 Jul 9.

Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections

Nivedita Srivastava  1 , Anil Kumar
Affiliations

Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections

Nivedita Srivastava et al. Eur J Med Chem. 2013 Sep.

Abstract

We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro.

Keywords: Antibacterial; Broad spectrum; Fluoroquinolone; Hydrazine; Quinolone; Sulfonamide.

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