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Editorial
. 2013 Sep;20(9):1128-30.
doi: 10.1038/cdd.2013.80.

dsDNA ASCs for caspase 8-mediated apoptosis

T Grabinger, P Peterburs, T Brunner
Editorial

dsDNA ASCs for caspase 8-mediated apoptosis

T Grabinger et al. Cell Death Differ. 2013 Sep.
No abstract available

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Figures

Figure 1
Figure 1
ASC-mediated switch between pyroptosis and apoptosis: intracellular pathogens and their products lead to activation of the ASC-dependent inflammasome. Strong inflammasome activation preferentially leads to caspase 1 recruitment and activation, and associated pyroptosis, IL-1β and IL-18 activation, and inflammation. Pathogen-derived inhibitors may prevent caspase 1 activation. Weak inflammasome activation promotes ASC-mediated caspase 8 recruitment and activation of the apoptotic pathway. Depending on the signaling cell type (type I or II), the mitochondrial signaling pathway may or may not be engaged
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References

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