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Comment
. 2013 Nov;10(6):453-5.
doi: 10.1038/cmi.2013.34. Epub 2013 Aug 12.

Regulatory roles of dermal type 2 innate lymphoid cells

Byungsuk Kwon
Comment

Regulatory roles of dermal type 2 innate lymphoid cells

Byungsuk Kwon. Cell Mol Immunol. 2013 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Roles of ILC2 in the skin under the steady state and during inflammation. (a) ILC2s interact with mast cells through unknown ligand–receptor pair interactions and suppress mast cell activation through the secretion of IL-13. IL-13-primed mast cells produce lower levels of pro-inflammatory cytokines (IL-6 and TNF) in response to allergens. ILC2s may also stimulate mast cells to produce immunomodulatory cytokines (IL-10 and TGF-β) through unknown receptor and IL-13R signaling. (b) Allergens induce keratinocyte to produce TSLP which results in the production of IL-4, IL-5, IL-9 and IL-13 effector cytokines for allergic responses. ILC2s may affect CD4+ T-cell differentiation through Th2 cytokine secretion. Cytokines (IL-2 and IL-9) of CD4+ T cells can induce ILC2s to produce Th2 cytokines. (c) ILC2s may uptake antigens and present them to CD4+ T cells in the context of MHC class II–peptide complex. If this occurs in the absence of costimulation, tolerogenic CD4+ T cells may be generated. ILC2, type 2 innate lymphoid cell.
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