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. 1990 Aug 31;171(1):7-13.
doi: 10.1016/0006-291x(90)91348-v.

The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon

G Crumley  1 , C A Dionne, M Jaye
Affiliations

The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon

G Crumley et al. Biochem Biophys Res Commun. .

Abstract

We have isolated two cDNA clones encoding human acidic fibroblast growth factor (aFGF) which represent the utilization of alternative upstream exons in aFGF mRNA. Isolation and sequence analysis of genomic clones spanning the first coding exon and each of the upstream sequences confirms that the divergent 5' sequences are separate exons, spliced alternatively to the first coding exon 34 nucleotides upstream of the initiator AUG codon. Restriction mapping of the genomic clones provides a minimum size estimate of 45 kilobase pairs for the aFGF locus.

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